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CAS No.: 64953-12-4

拉氧头孢钠 Catalog No. CSN11475

Synonyms: Moxalactam Sodium

Moxalactam sodium is an antibiotic compound more effective against Escherichia coli and Pseudomonas aeruginosathan cephalosporins.

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技术信息

生物活性

描述Moxalactam (Sodium) is a new synthetic oxa-beta-lactam antibiotic administered intravenously or intramuscularly. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, is particularly active against Enterobacteriaceae and is resistant to hydrolysis by beta-lactamases^[2]. Moxalactam showed great antibacterial activity to Enterobacteriaceae spp., including ESBLs-producing Escherichia coli, Klebsiella pneumoniae, and Proteus spp., with the MIC(50), MIC(90), and susceptibility rates of 0.25-4 mg/L, 0.5-8 mg/L, and >90%, respectively. Moxalactam showed well activity against ESBLs-producing and non-ESBLs-producing Enterobacteriaceae and anaerobia^[3]. Moxalactam appears to be a safe, effective drug for complicated urinary tract infections caused by susceptible bacteria, including those resistant to gentamicin^[4]. The levels of moxalactam achieved in CSF (cerebrospinal fluid) greatly exceeded the minimal bactericidal concentrations for the infecting organisms. Moxalactam appears to be safe and effective as primary therapy for meningitis caused by H influenzae or N meningitidis^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7717 mL
- 8.8584 mL
- 17.7168 mL
- 5 mM
- 0.3543 mL
- 1.7717 mL
- 3.5434 mL
- 10 mM
- 0.1772 mL
- 0.8858 mL
- 1.7717 mL

技术信息

CAS号

64953-12-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H18N6Na2O9S

运输

蓝冰

分子量

564.44

别名

Moxalactam Sodium

溶解度

DMSO	103.0 mg/mL (182.5 mM)
Water	135.0 mg/mL (239.2 mM)

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